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Oxidative stress in granulosa cells contributes to poor oocyte quality and IVF-ET outcomes in women with

Qiaohong Lai, Wenpei Xiang, Qing Li, Hanwang Zhang, Yufeng Li, Guijin Zhu, Chengliang Xiong, Lei Jin

Frontiers of Medicine 2018, Volume 12, Issue 5, Pages 518-524 doi: 10.1007/s11684-017-0575-y

Abstract:

The increased levels of intracellular reactive oxygen species (ROS) in granulosa cells (GCs) may affectIn conclusion, the increased ROS expression levels in PCOS GCs greatly induced cell apoptosis, which

Keywords： PCOS ROS granulosa cell IVF-ET NADPH oxidase

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Microfluidics for cell-cell interactions: A review

Rui Li,Xuefei Lv,Xingjian Zhang,Omer Saeed,Yulin Deng

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 1, Pages 90-98 doi: 10.1007/s11705-015-1550-2

Abstract: The well-designed microscale intermediary is also ideal for the study of cell biology.Particularly, microfluidic chip is helpful for better understanding cell-cell interactions.

Keywords： microfluidic chip co-culture cell-cell interactions review

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Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in

Frontiers of Medicine Pages 939-956 doi: 10.1007/s11684-023-0987-9

Abstract: 645 cardiac cells were generated from embryonic day 17.5 and postnatal days 2 and 8 mice by single-cellMNDCMs having interactions with macrophages and non-proliferative MNDCMs (non-pMNDCMs) with minimal cell–cellThese MNDCMs were mapped to the heart by integrating the spatial and single-cell transcriptomic data.In conclusion, a novel non-pMNDCM subpopulation with minimal cell–cell communications was unveiled, highlighting

Keywords： mononuclear diploid cardiomyocytes cell–cell communication cardiac fibroblast single-cell RNA sequencing

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Deubiquitinases as pivotal regulators of T cell functions

Xiao-Dong Yang, Shao-Cong Sun

Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 451-462 doi: 10.1007/s11684-018-0651-y

Abstract: Defect in T cell activation is associated with severe immune deficiencies, whereas aberrant T cell activationAn emerging mechanism that regulates T cell activation and tolerance is ubiquitination, a reversibleIt is now well recognized that DUBs are crucial regulators of T cell responses and serve as potential

Keywords： deubiquitinase ubiquitination T cell activation T cell differentiation T cell tolerance

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Cell surface protein engineering for high-performance whole-cell catalysts

Hajime Nakatani,Katsutoshi Hori

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1, Pages 46-57 doi: 10.1007/s11705-017-1609-3

Abstract: Cell surface protein engineering facilitated by accumulation of information on genome and protein structureinvolves heterologous production and modification of cell surface proteins using genetic engineering, and is important for the development of high-performance whole-cell catalysts.In this field, cell surface display is a major technology by exposing target proteins, such as enzymes, on the cell surface using a carrier protein.

Keywords： cell surface engineering surface display whole-cell catalysts bioprocess

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Stem cell niches and endogenous electric fields in tissue repair

Li LI, Jianxin JIANG

Frontiers of Medicine 2011, Volume 5, Issue 1, Pages 40-44 doi: 10.1007/s11684-011-0108-z

Abstract: Endogenous adult stem cells reside in certain regions of organs, known as the stem cell niche, whichMany regulatory factors are involved in the stem cell-based repair process, including stem cell nichesHere we briefly review the role of stem cell niches and endogenous electric fields in tissue repair,and hypothesize that endogenous electric fields become part of stem cell niche in the wound site.

Keywords： stem cell stem cell niche electric field tissue repair

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CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies

Frontiers of Medicine 2021, Volume 15, Issue 6, Pages 783-804 doi: 10.1007/s11684-021-0904-z

Abstract: Chimeric antigen receptor T-cell (CAR T) immunotherapy opens a new path for targeted therapy of hematologicalIn this review, through a representative case study, we summarize the current experience of CAR T-cellthe causative mechanisms of therapy resistance, and new strategies to improve the efficacy of CAR T-cell

Keywords： CAR T cells hematological malignancies review

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Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Frontiers of Medicine 2023, Volume 17, Issue 3, Pages 503-517 doi: 10.1007/s11684-022-0947-9

Abstract: Aldolase B (ALDOB), a glycolytic enzyme, is uniformly depleted in clear cell renal cell carcinoma (ccRCCALDOB inhibited CtBP2-mediated repression of multiple cell cycle inhibitor, proapoptotic, and epithelial

Keywords： ALDOB kidney cancer cell proliferation

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The unregulated commercialization of stem cell treatments: a global perspective

Douglas Sipp

Frontiers of Medicine 2011, Volume 5, Issue 4, Pages 348-355 doi: 10.1007/s11684-011-0150-x

Abstract: notwithstanding, hundreds of companies and private clinics around the world now sell putative stem cellIn this review, I provide an overview of the global industry in pseudomedical stem cell treatments, with

Keywords： stem cell tourism medical ethics stem cell policy and regulation alternative medicine

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Fine-tuning cell organelle dynamics during mitosis by small GTPases

Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 339-357 doi: 10.1007/s11684-022-0926-1

Abstract: coordination of genetic material inheritance with organelle dynamics directs accurate mitotic progression, cellSmall GTPases belonging to the Ras superfamily regulate various cell organelles during division.the key regulators of membrane dynamics, the dysregulation of small GTPases is widely associated with cellThis review collects current knowledge on small GTPases in the regulation of cell organelles during mitosisand highlights the mediator role of small GTPase in transducing cell cycle signaling to organelle dynamics

Keywords： small GTPase cell organelle mitosis

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A comprehensive assessment on the durability of gas diffusion electrode materials in PEM fuel cell stack

Arunkumar JAYAKUMAR

Frontiers in Energy 2019, Volume 13, Issue 2, Pages 325-338 doi: 10.1007/s11708-019-0618-y

Abstract: Polymer electrolyte membrane (PEM) fuel cell is the most promising among the various types of fuel cellsnumerous fields, the cost and durability are key barriers impeding the commercialization of PEM fuel cellgas diffusion electrode (GDE) and its degradation, which limits the performance and life of the fuel cell

Keywords： PEM fuel cell gas diffusion electrode(GDE) gas diffusion layer(GDL) membrane electrode assembly durability fuel cell catalyst

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Highlights of mainstream solar cell efficiencies in 2021

Frontiers in Energy 2022, Volume 16, Issue 1, Pages 1-8 doi: 10.1007/s11708-022-0816-x

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A hybrid fuel cell for water purification and simultaneously electricity generation

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 1, doi: 10.1007/s11783-023-1611-6

Abstract:

● A novel hybrid fuel cell (F-HFC) was fabricated.

Keywords： Flow-through field Hybrid fuel cell Polyoxometalates Water purification Electricity generation

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Highlights of mainstream solar cell efficiencies in 2022

Frontiers in Energy 2023, Volume 17, Issue 1, Pages 9-15 doi: 10.1007/s11708-023-0871-y

Abstract: Highlights of mainstream solar cell efficiencies in 2022

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Discovery of small molecule degraders for modulating cell cycle

Frontiers of Medicine Pages 823-854 doi: 10.1007/s11684-023-1027-5

Abstract: The cell cycle is a complex process that involves DNA replication, protein expression, and cell divisionDysregulation of the cell cycle is associated with various diseases.Cyclin-dependent kinases (CDKs) and their corresponding cyclins are major proteins that regulate the cell

Keywords： PROTAC molecular glue degrader cell cycle CDK cyclin